 |
Thanawastien A, Montor WR, Labaer J, Mekalanos JJ, Yoon SS. Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel Toll-like receptor 4 agonist. PLoS Pathog. 2009 Aug;5(8):e1000556. PubMed |
| Ma AT, McAuley S, Pukatzki S, Mekalanos JJ. Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. Cell Host Microbe. 2009 Mar 19. 5(3):234-43. PubMed | |
|
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ. Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proc Natl Acad Sci U S A. 2009 Mar 17. 106(11):4154-9. PubMed |
|
Zahid MS, Udden SM, Faruque AS, Calderwood SB, Mekalanos JJ, Faruque SM. Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants. Infect Immun. 2008 Nov. 76(11):5266-73. PubMed |
|
Udden SM, Zahid MS, Biswas K, Ahmad QS, Cravioto A, Nair GB, Mekalanos JJ, Faruque SM. Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence. Proc Natl Acad Sci U S A. 2008 Aug 19. 105(33):11951-6. PubMed |
| Rhie GE, Jung HM, Kim BS, Mekalanos JJ. Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associated cholera toxin B subunit. Vaccine. 2008 Oct 9. 26(43):5443-8 PubMed | |
|
Cameron, D.E., Urbach, J.M., Mekalanos, J.J., A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae. Proc Natl Acad Sci U S A, 2008. 105(25): 8736-41. PubMed |
| Rahman, J.H., Biswas, K., Hossain, M.A., Sack, R.B., Mekalanos, J.J., Faruque, S.M. Distribution of genes for virulence and ecological fitness among diverse Vibrio cholerae population in a cholera endemic area: tracking the evolution of pathogenic strains. DNA Cell Biol. 2008 Jul. 27(7):347-55. PubMed | |
|
Rolfs A, Montor WR, Yoon SS, Hu Y, Bhullar B, Kelley F, McCarron S, Jepson DA, Shen B, Taycher E, Mohr SE, Zuo D, Williamson J, Mekalanos J, Labaer J. Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4364-9. PubMed |
| Yoon, S.S., Mekalanos, J.J., Decreased Potency of Vibrio cholerae Sheathed Flagellum to Trigger Host Innate Immunity. Infect Immun. 2008 Jan 3. PubMed | |
| Rhie, G.E., Jung, H.M., Prark, J., Kim, B.S., Mekalanos, J.J., Construction of cholera toxin B subunit-producing Vibrio cholerae strains using the Mariner-FRT transposon delivery system. FEMS Immunol Med Microbiol. 2008 Jan;52(1):23-8. PubMed | |
| Shakhnovich, E.A., Sturtevant, D., Mekalanos, J.J., Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae. Mol Microbiol., 2007. PubMed | |
|
Pukatzki, S., Ma, A.T., Revel, A.T., Sturtevant, D., Mekalanos, J. J. , Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc Natl Acad Sci U S A, 2007. 104(39): p. 15508-13. PubMed |
|
Mougous, J.D., Gifford, C.A., Ramsdell, T.L., Mekalanos, J. J. , Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nature Cell Biology, 2007. 9(7): p. 797-803. PubMed |
|
Tam, V.C., Serruto, D., Dziejman, M., Brieher, W., Mekalanos, J. J. , A Type III Secretion System in Vibrio cholerae translocates a Formin/Spire hybrid-like actin nucleator to promote intestinal colonization. Cell Host & Microbe, 2007. 1(2): p. 95-107. PubMed |
|
Smith, M.G., Gianoulis, T.A., Pukatzki, S., Mekalanos, J.J., Ornston, L.N., Gerstein, M., and Snyder, M., New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev, 2007. 21(5): p. 601-14. PubMed |
|
Shakhnovich, E.A., Hung, D.T., Pierson, E., Lee, K., and Mekalanos, J.J., Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A, 2007. 104(7): p. 2372-7. PubMed |
|
Raskin, D.M., Judson, N., and Mekalanos, J.J., Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae. Proc Natl Acad Sci U S A, 2007. 104(11): p. 4636-41. PubMed |
|
Qadri, F., Chowdhury, M.I., Faruque, S.M., Salam, M.A., Ahmed, T., Begum, Y.A., Saha, A., Al Tarique, A., Seidlein, L.V., Park, E., Killeen, K.P., Mekalanos, J.J., Clemens, J.D., and Sack, D.A., Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants. Vaccine, 2007. 25(2): p. 231-8. PubMed |
|
Faruque, S.M., Tam, V.C., Chowdhury, N., Diraphat, P., Dziejman, M., Heidelberg, J.F., Clemens, J.D., Mekalanos, J.J., and Nair, G.B., Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage. Proc Natl Acad Sci U S A, 2007. 104(12): p. 5151-6. PubMed |
|
Yoon, S.S. and Mekalanos, J.J., 2,3-butanediol synthesis and the emergence of the Vibrio cholerae El Tor biotype. Infect Immun, 2006. 74(12): p. 6547-56. PubMed |
|
Rietsch, A. and Mekalanos, J.J., Metabolic regulation of type III secretion gene expression in Pseudomonas aeruginosa. Mol Microbiol, 2006. 59(3): p. 807-20. PubMed |
|
Raskin, D.M., Seshadri, R., Pukatzki, S.U., and Mekalanos, J.J., Bacterial genomics and pathogen evolution. Cell, 2006. 124(4): p. 703-14. PubMed |
|
Pukatzki, S., Ma, A.T., Sturtevant, D., Krastins, B., Sarracino, D., Nelson, W.C., Heidelberg, J.F., and Mekalanos, J.J., Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A, 2006. 103(5): p. 1528-33. PubMed |
| |
Mougous, J.D., Cuff, M.E., Raunser, S., Shen, A., Zhou, M., Gifford, C.A., Goodman, A.L., Joachimiak, G., Ordonez, C.L., Lory, S., Walz, T., Joachimiak, A., and Mekalanos, J.J., A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science, 2006. 312(5779): p. 1526-30. PubMed |
|
Jensen, M.A., Faruque, S.M., Mekalanos, J.J., and Levin, B.R., Modeling the role of bacteriophage in the control of cholera outbreaks. Proc Natl Acad Sci U S A, 2006. 103(12): p. 4652-7. PubMed |
|
Hung, D.T., Zhu, J., Sturtevant, D., and Mekalanos, J.J., Bile acids stimulate biofilm formation in Vibrio cholerae. Mol Microbiol, 2006. 59(1): p. 193-201. PubMed |
|
Faruque, S.M., Islam, M.J., Ahmad, Q.S., Biswas, K., Faruque, A.S., Nair, G.B., Sack, R.B., Sack, D.A., and Mekalanos, J.J., An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: monitoring the emergence of a multiple-antibiotic-resistant epidemic strain in Bangladesh. J Infect Dis, 2006. 193(7): p. 1029-36. PubMed |
|
Faruque, S.M., Biswas, K., Udden, S.M., Ahmad, Q.S., Sack, D.A., Nair, G.B., and Mekalanos, J.J., Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment. Proc Natl Acad Sci U S A, 2006. 103(16): p. 6350-5. PubMed |
|
Bina, J.E., Provenzano, D., Wang, C., Bina, X.R., and Mekalanos, J.J., Characterization of the Vibrio cholerae vexAB and vexCD efflux systems. Arch Microbiol, 2006. 186(3): p. 171-81. PubMed |
|
Vance, R.E., Rietsch, A., and Mekalanos, J.J., Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo. Infect Immun, 2005. 73(3): p. 1706-13. PubMed |
|
Rietsch, A., Vallet-Gely, I., Dove, S.L., and Mekalanos, J.J., ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A, 2005. 102(22): p. 8006-11. PubMed |
|
Qadri, F., Chowdhury, M.I., Faruque, S.M., Salam, M.A., Ahmed, T., Begum, Y.A., Saha, A., Alam, M.S., Zaman, K., Seidlein, L.V., Park, E., Killeen, K.P., Mekalanos, J.J., Clemens, J.D., and Sack, D.A., Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh. J Infect Dis, 2005. 192(4): p. 573-9. PubMed |
|
Larocque, R.C., Harris, J.B., Dziejman, M., Li, X., Khan, A.I., Faruque, A.S., Faruque, S.M., Nair, G.B., Ryan, E.T., Qadri, F., Mekalanos, J.J., and Calderwood, S.B., Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infect Immun, 2005. 73(8):p. 4488-93. PubMed |
|
Hung, D.T., Shakhnovich, E.A., Pierson, E., and Mekalanos, J.J., Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science, 2005. 310(5748): p. 670-4. PubMed |
|
Hung, D.T. and Mekalanos, J.J., Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proc Natl Acad Sci U S A, 2005. 102(8): p. 3028-33. PubMed |
|
Faruque, S.M., Naser, I.B., Islam, M.J., Faruque, A.S., Ghosh, A.N., Nair, G.B., Sack, D.A., and Mekalanos, J.J., Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages. Proc Natl Acad Sci U S A, 2005. 102(5): p. 1702-7. PubMed |
|
Faruque, S.M., Islam, M.J., Ahmad, Q.S., Faruque, A.S., Sack, D.A., Nair, G.B., and Mekalanos, J.J., Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage. Proc Natl Acad Sci U S A, 2005. 102(17): p. 6119-24. PubMed |
|
Faruque, S.M., Bin Naser, I., Fujihara, K., Diraphat, P., Chowdhury, N., Kamruzzaman, M., Qadri, F., Yamasaki, S., Ghosh, A.N., and Mekalanos, J.J., Genomic sequence and receptor for the Vibrio cholerae phage KSF-1phi: evolutionary divergence among filamentous vibriophages mediating lateral gene transfer. J Bacteriol, 2005. 187(12): p. 4095-103. PubMed |
|
Dziejman, M., Serruto, D., Tam, V.C., Sturtevant, D., Diraphat, P., Faruque, S.M., Rahman, M.H., Heidelberg, J.F., Decker, J., Li, L., Montgomery, K.T., Grills, G., Kucherlapati, R., and Mekalanos, J.J., Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. Proc Natl Acad Sci U S A, 2005. 102(9): p. 3465-70. PubMed |
|
Aulinger, B.A., Roehrl, M.H., Mekalanos, J.J., Collier, R.J., and Wang, J.Y., Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun, 2005. 73(6): p. 3408-14. PubMed |
|
Altman, S., Bassler, B.L., Beckwith, J., Belfort, M., Berg, H.C., Bloom, B., Brenchley, J.E., Campbell, A., Collier, R.J., Connell, N., Cozzarelli, N.R., Craig, N.L., Darst, S., Ebright, R.H., Elledge, S.J., Falkow, S., Galan, J.E., Gottesman, M., Gourse, R., Grindley, N.D., Gross, C.A., Grossman, A., Hochschild, A., Howe, M., Hurwitz, J., Isberg, R.R., Kaplan, S., Kornberg, A., Kustu, S.G., Landick, R.C., Landy, A., Levy, S.B., Losick, R., Long, S.R., Maloy, S.R., Mekalanos, J.J., Neidhardt, F.C., Pace, N.R., Ptashne, M., Roberts, J.W., Roth, J.R., Rothman-Denes, L.B., Salyers, A., Schaechter, M., Shapiro, L., Silhavy, T.J., Simon, M.I., Walker, G., Yanofsky, C., and Zinder, N., An open letter to Elias Zerhouni. Science, 2005. 307(5714): p. 1409-10. PubMed |
|
Vance, R.E., Hong, S., Gronert, K., Serhan, C.N., and Mekalanos, J.J., The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc Natl Acad Sci U S A, 2004. 101(7): p. 2135-9. PubMed |
|
Rietsch, A., Wolfgang, M.C., and Mekalanos, J.J., Effect of metabolic imbalance on expression of type III secretion genes in Pseudomonas aeruginosa. Infect Immun, 2004. 72(3): p. 1383-90. PubMed |
| Jonsson, K., Guo, B.P., Monstein, H.J., Mekalanos, J.J., and Kronvall, G., Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins. Proc Natl Acad Sci U S A, 2004. 101(7): p. 1852-7. PubMed | |
| Faruque, S.M., Nair, G.B., and Mekalanos, J.J., Genetics of stress adaptation and virulence in toxigenic Vibrio cholerae. DNA Cell Biol, 2004. 23(11): p. 723-41. PubMed | |
| Faruque, S.M., Chowdhury, N., Kamruzzaman, M., Dziejman, M., Rahman, M.H., Sack, D.A., Nair, G.B., and Mekalanos, J.J., Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area. Proc Natl Acad Sci U S A, 2004. 101(7): p. 2123-8. PubMed | |
| Zhu, J. and Mekalanos, J.J., Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae. Dev Cell, 2003. 5(4): p. 647-56. PubMed | |
| Xu, Q., Dziejman, M., and Mekalanos, J.J., Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitro. Proc Natl Acad Sci U S A, 2003. 100(3): p. 1286-91. PubMed | |
| Vance, R.E., Zhu, J., and Mekalanos, J.J., A constitutively active variant of the quorum-sensing regulator LuxO affects protease production and biofilm formation in Vibrio cholerae. Infect Immun, 2003. 71(5): p. 2571-6. PubMed | |
| Rhie, G.E., Roehrl, M.H., Mourez, M., Collier, R.J., Mekalanos, J.J., and Wang, J.Y., A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci U S A, 2003. 100(19): p. 10925-30. PubMed | |
| Faruque, S.M., Zhu, J., Asadulghani, Kamruzzaman, M., and Mekalanos, J.J., Examination of diverse toxin-coregulated pilus-positive Vibrio cholerae strains fails to demonstrate evidence for Vibrio pathogenicity island phage. Infect Immun, 2003. 71(6): p. 2993-9. PubMed | |
| Faruque, S.M. and Mekalanos, J.J., Pathogenicity islands and phages in Vibrio cholerae evolution. Trends Microbiol, 2003. 11(11): p. 505-10. PubMed | |
| Faruque, S.M., Kamruzzaman, M., Asadulghani, Sack, D.A., Mekalanos, J.J., and Nair, G.B., CTXphi-independent production of the RS1 satellite phage by Vibrio cholerae. Proc Natl Acad Sci U S A, 2003. 100(3): p. 1280-5. PubMed | |
| Bina, J., Zhu, J., Dziejman, M., Faruque, S., Calderwood, S., and Mekalanos, J., ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients. Proc Natl Acad Sci U S A, 2003. 100(5): p. 2801-6. PubMed | |
| Zhu, J., Miller, M.B., Vance, R.E., Dziejman, M., Bassler, B.L., and Mekalanos, J.J., Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci U S A, 2002. 99(5): p. 3129-34. PubMed | |
| Pukatzki, S., Kessin, R.H., and Mekalanos, J.J., The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum. Proc Natl Acad Sci U S A, 2002. 99(5): p. 3159-64. PubMed | |
| Guo, B.P. and Mekalanos, J.J., Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice. Proc Natl Acad Sci U S A, 2002. 99(12): p. 8354-9. PubMed | |
| Fullner, K.J., Boucher, J.C., Hanes, M.A., Haines, G.K., 3rd, Meehan, B.M., Walchle, C., Sansonetti, P.J., and Mekalanos, J.J., The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. J Exp Med, 2002. 195(11): p. 1455-62. PubMed | |
| Faruque, S.M., Asadulghani, Kamruzzaman, M., Nandi, R.K., Ghosh, A.N., Nair, G.B., Mekalanos, J.J., and Sack, D.A., RS1 element of Vibrio cholerae can propagate horizontally as a filamentous phage exploiting the morphogenesis genes of CTXphi. Infect Immun, 2002. 70(1): p. 163-70. PubMed | |
| Dziejman, M., Balon, E., Boyd, D., Fraser, C.M., Heidelberg, J.F., and Mekalanos, J.J., Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease. Proc Natl Acad Sci U S A, 2002. 99(3): p. 1556-61. PubMed | |
| Buddelmeijer, N., Judson, N., Boyd, D., Mekalanos, J.J., and Beckwith, J., YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Proc Natl Acad Sci U S A, 2002. 99(9): p. 6316-21. PubMed | |
| Akerley, B.J., Rubin, E.J., Novick, V.L., Amaya, K., Judson, N., and Mekalanos, J.J., A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc Natl Acad Sci U S A, 2002. 99(2): p. 966-71. PubMed | |
| Guo, B.P. and Mekalanos, J.J., Helicobacter pylori mutagenesis by mariner in vitro transposition. FEMS Immunol Med Microbiol, 2001. 30(2): p. 87-93. PubMed | |
| Fullner, K.J., Lencer, W.I., and Mekalanos, J.J., Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin. Infect Immun, 2001. 69(10): p. 6310-7. PubMed | |
| Faruque, S.M., Rahman, M.M., Hasan, A.K., Nair, G.B., Mekalanos, J.J., and Sack, D.A., Diminished diarrheal response to Vibrio cholerae strains carrying the replicative form of the CTX(Phi) genome instead of CTX(Phi) lysogens in adult rabbits. Infect Immun, 2001. 69(10): p. 6084-90. PubMed | |
| Dalsgaard, A., Serichantalergs, O., Forslund, A., Lin, W., Mekalanos, J., Mintz, E., Shimada, T., and Wells, J.G., Clinical and environmental isolates of Vibrio cholerae serogroup O141 carry the CTX phage and the genes encoding the toxin-coregulated pili. J Clin Microbiol, 2001. 39(11): p. 4086-92. PubMed | |
| Cassell, G.H. and Mekalanos, J., Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance. Jama, 2001. 285(5): p. 601-5. PubMed | |
| Bina, J.E. and Mekalanos, J.J., Vibrio cholerae tolC is required for bile resistance and colonization. Infect Immun, 2001. 69(7): p. 4681-5. PubMed | |
| Wong, S.M. and Mekalanos, J.J., Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A, 2000. 97(18): p. 10191-6. PubMed | |
| Mel, S.F., Fullner, K.J., Wimer-Mackin, S., Lencer, W.I., and Mekalanos, J.J., Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells. Infect Immun, 2000. 68(11): p. 6487-92. PubMed | |
| Keen, N., Staskawicz, B., Mekalanos, J., Ausubel, F., and Cook, R.J., Pathogens and hosts: the dance is the same, the couples are different. Proc Natl Acad Sci U S A, 2000. 97(16): p. 8752-3. PubMed | |
| Judson, N. and Mekalanos, J.J., Transposon-based approaches to identify essential bacterial genes. Trends Microbiol, 2000. 8(11): p. 521-6. PubMed | |
| Judson, N. and Mekalanos, J.J., TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes. Nat Biotechnol, 2000. 18(7): p. 740-5. PubMed | |
| Jain, V. and Mekalanos, J.J., Use of lambda phage S and R gene products in an inducible lysis system for Vibrio cholerae- and Salmonella enterica serovar typhimurium-based DNA vaccine delivery systems. Infect Immun, 2000. 68(2): p. 986-9. PubMed | |
| Heidelberg, J.F., Eisen, J.A., Nelson, W.C., Clayton, R.A., Gwinn, M.L., Dodson, R.J., Haft, D.H., Hickey, E.K., Peterson, J.D., Umayam, L., Gill, S.R., Nelson, K.E., Read, T.D., Tettelin, H., Richardson, D., Ermolaeva, M.D., Vamathevan, J., Bass, S., Qin, H., Dragoi, I., Sellers, P., McDonald, L., Utterback, T., Fleishmann, R.D., Nierman, W.C., White, O., Salzberg, S.L., Smith, H.O., Colwell, R.R., Mekalanos, J.J., Venter, J.C., and Fraser, C.M., DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature, 2000. 406(6795): p. 477-83. PubMed | |
| Fullner, K.J. and Mekalanos, J.J., In vivo covalent cross-linking of cellular actin by the Vibrio cholerae RTX toxin. Embo J, 2000. 19(20): p. 5315-23. PubMed | |
| Chiang, S.L. and Mekalanos, J.J., Construction of a Vibrio cholerae vaccine candidate using transposon delivery and FLP recombinase-mediated excision. Infect Immun, 2000. 68(11): p. 6391-7. PubMed | |
| Blum, J.H., Dove, S.L., Hochschild, A., and Mekalanos, J.J., Isolation of peptide aptamers that inhibit intracellular processes. Proc Natl Acad Sci U S A, 2000. 97(5): p. 2241-6. PubMed |
| Rubin, E.J., Akerley, B.J., Novik, V.N., Lampe, D.J., Husson, R.N., and Mekalanos, J.J., In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria. Proc Natl Acad Sci U S A, 1999. 96(4): p. 1645-50. PubMed | |
| Lin, W., Fullner, K.J., Clayton, R., Sexton, J.A., Rogers, M.B., Calia, K.E., Calderwood, S.B., Fraser, C., and Mekalanos, J.J., Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Proc Natl Acad Sci U S A, 1999. 96(3): p. 1071-6. PubMed | |
| Lampe, D.J., Akerley, B.J., Rubin, E.J., Mekalanos, J.J., and Robertson, H.M., Hyperactive transposase mutants of the Himar1 mariner transposon. Proc Natl Acad Sci U S A, 1999. 96(20): p. 11428-33. PubMed | |
| Killeen, K., Spriggs, D., and Mekalanos, J., Bacterial mucosal vaccines: Vibrio cholerae as a live attenuated vaccine/vector paradigm. Curr Top Microbiol Immunol, 1999. 236: p. 237-54. PubMed | |
| Hase, C.C. and Mekalanos, J.J., Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci U S A, 1999. 96(6): p. 3183-7. PubMed | |
| Fullner, K.J. and Mekalanos, J.J., Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae. Infect Immun, 1999. 67(3): p. 1393-404. PubMed | |
| Faruque, S.M., Rahman, M.M., Asadulghani, Nasirul Islam, K.M., and Mekalanos, J.J., Lysogenic conversion of environmental Vibrio mimicus strains by CTXPhi. Infect Immun, 1999. 67(11): p. 5723-9. PubMed | |
| Dziejman, M., Kolmar, H., Fritz, H.J., and Mekalanos, J.J., ToxR co-operative interactions are not modulated by environmental conditions or periplasmic domain conformation. Mol Microbiol, 1999. 31(1): p. 305-17. PubMed | |
| Chiang, S.L., Mekalanos, J.J., and Holden, D.W., In vivo genetic analysis of bacterial virulence. Annu Rev Microbiol, 1999. 53: p. 129-54. PubMed | |
| Chiang, S.L. and Mekalanos, J.J., rfb mutations in Vibrio cholerae do not affect surface production of toxin-coregulated pili but still inhibit intestinal colonization. Infect Immun, 1999. 67(2): p. 976-80. PubMed | |
| Rubin, E.J., Lin, W., Mekalanos, J.J., and Waldor, M.K., Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage. Mol Microbiol, 1998. 28(6): p. 1247-54. PubMed | |
| Meno, Y., Waldor, M.K., Mekalanos, J.J., and Amako, K., Morphological and physical characterization of the capsular layer of Vibrio cholerae O139. Arch Microbiol, 1998. 170(5): p. 339-44. PubMed | |
| Martinez de Tejada, G., Cotter, P.A., Heininger, U., Camilli, A., Akerley, B.J., Mekalanos, J.J., and Miller, J.F., Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice. Infect Immun, 1998. 66(6): p. 2762-8. PubMed | |
| Lee, S.H., Angelichio, M.J., Mekalanos, J.J., and Camilli, A., Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection. J Bacteriol, 1998. 180(9): p. 2298-305. PubMed | |
| Klose, K.E., Novik, V., and Mekalanos, J.J., Identification of multiple sigma54-dependent transcriptional activators in Vibrio cholerae. J Bacteriol, 1998. 180(19): p. 5256-9. PubMed | |
| Klose, K.E. and Mekalanos, J.J., Distinct roles of an alternative sigma factor during both free-swimming and colonizing phases of the Vibrio cholerae pathogenic cycle. Mol Microbiol, 1998. 28(3): p. 501-20. PubMed | |
| Klose, K.E. and Mekalanos, J.J., Differential regulation of multiple flagellins in Vibrio cholerae. J Bacteriol, 1998. 180(2): p. 303-16. PubMed | |
| Hase, C.C. and Mekalanos, J.J., TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci U S A, 1998. 95(2): p. 730-4. PubMed | |
| Faruque, S.M., Asadulghani, Saha, M.N., Alim, A.R., Albert, M.J., Islam, K.M., and Mekalanos, J.J., Analysis of clinical and environmental strains of nontoxigenic Vibrio cholerae for susceptibility to CTXPhi: molecular basis for origination of new strains with epidemic potential. Infect Immun, 1998. 66(12): p. 5819-25. PubMed | |
| Faruque, S.M., Asadulghani, Alim, A.R., Albert, M.J., Islam, K.M., and Mekalanos, J.J., Induction of the lysogenic phage encoding cholera toxin in naturally occurring strains of toxigenic Vibrio cholerae O1 and O139. Infect Immun, 1998. 66(8): p. 3752-7. PubMed | |
| Faruque, S.M., Albert, M.J., and Mekalanos, J.J., Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae. Microbiol Mol Biol Rev, 1998. 62(4): p. 1301-14. PubMed | |
| Chiang, S.L. and Mekalanos, J.J., Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization. Mol Microbiol, 1998. 27(4): p. 797-805. PubMed | |
| Akerley, B.J., Rubin, E.J., Camilli, A., Lampe, D.J., Robertson, H.M., and Mekalanos, J.J., Systematic identification of essential genes by in vitro mariner mutagenesis. Proc Natl Acad Sci U S A, 1998. 95(15): p. 8927-32. PubMed | |
| Acheson, D.W., Reidl, J., Zhang, X., Keusch, G.T., Mekalanos, J.J., and Waldor, M.K., In vivo transduction with shiga toxin 1-encoding phage. Infect Immun, 1998. 66(9): p. 4496-8. PubMed | |
| Waldor, M.K., Rubin, E.J., Pearson, G.D., Kimsey, H., and Mekalanos, J.J., Regulation, replication, and integration functions of the Vibrio cholerae CTXphi are encoded by region RS2. Mol Microbiol, 1997. 24(5): p. 917-26. PubMed | |
| Mekalanos, J.J., Rubin, E.J., and Waldor, M.K., Cholera: molecular basis for emergence and pathogenesis. FEMS Immunol Med Microbiol, 1997. 18(4): p. 241-8. PubMed | |
| Klose, K.E. and Mekalanos, J.J., Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence. Infect Immun, 1997. 65(2): p. 587-96. PubMed | |
| Waldor, M.K., Tschape, H., and Mekalanos, J.J., A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139. J Bacteriol, 1996. 178(14): p. 4157-65. PubMed | |
| Waldor, M.K. and Mekalanos, J.J., Lysogenic conversion by a filamentous phage encoding cholera toxin. Science, 1996. 272(5270): p. 1910-4. PubMed | |
| Slauch, J.M., Lee, A.A., Mahan, M.J., and Mekalanos, J.J., Molecular characterization of the oafA locus responsible for acetylation of Salmonella typhimurium O-antigen: oafA is a member of a family of integral membrane trans-acylases. J Bacteriol, 1996. 178(20): p. 5904-9. PubMed | |
| Reidl, J. and Mekalanos, J.J., Lipoprotein e(P4) is essential for hemin uptake by Haemophilus influenzae. J Exp Med, 1996. 183(2): p. 621-9. PubMed | |
| Ottemann, K.M. and Mekalanos, J.J., The ToxR protein of Vibrio cholerae forms homodimers and heterodimers. J Bacteriol, 1996. 178(1): p. 156-62. PubMed | |
| Mel, S.F. and Mekalanos, J.J., Modulation of horizontal gene transfer in pathogenic bacteria by in vivo signals. Cell, 1996. 87(5): p. 795-8. PubMed | |
| Gardel, C.L. and Mekalanos, J.J., Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression. Infect Immun, 1996. 64(6): p. 2246-55. PubMed | |
| Slauch, J.M., Mahan, M.J., Michetti, P., Neutra, M.R., and Mekalanos, J.J., Acetylation (O-factor 5) affects the structural and immunological properties of Salmonella typhimurium lipopolysaccharide O antigen. Infect Immun, 1995. 63(2): p. 437-41. PubMed | |
| Reidl, J. and Mekalanos, J.J., Characterization of Vibrio cholerae bacteriophage K139 and use of a novel mini-transposon to identify a phage-encoded virulence factor. Mol Microbiol, 1995. 18(4): p. 685-701. PubMed | |
| Ottemann, K.M. and Mekalanos, J.J., Analysis of Vibrio cholerae ToxR function by construction of novel fusion proteins. Mol Microbiol, 1995. 15(4): p. 719-31. PubMed | |
| Mahan, M.J., Tobias, J.W., Slauch, J.M., Hanna, P.C., Collier, R.J., and Mekalanos, J.J., Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host. Proc Natl Acad Sci U S A, 1995. 92(3): p. 669-73. PubMed | |
| Coster, T.S., Killeen, K.P., Waldor, M.K., Beattie, D.T., Spriggs, D.R., Kenner, J.R., Trofa, A., Sadoff, J.C., Mekalanos, J.J., and Taylor, D.N., Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae O139 vaccine prototype. Lancet, 1995. 345(8955): p. 949-52. PubMed | |
| Chiang, S.L., Taylor, R.K., Koomey, M., and Mekalanos, J.J., Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance. Mol Microbiol, 1995. 17(6): p. 1133-42. PubMed | |
| Carter, R.M., Mekalanos, J.J., Jacobs, M.B., Lubrano, G.J., and Guilbault, G.G., Quartz crystal microbalance detection of Vibrio cholerae O139 serotype. J Immunol Methods, 1995. 187(1): p. 121-5. PubMed | |
| Camilli, A. and Mekalanos, J.J., Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection. Mol Microbiol, 1995. 18(4): p. 671-83. PubMed | |
| Butterton, J.R., Beattie, D.T., Gardel, C.L., Carroll, P.A., Hyman, T., Killeen, K.P., Mekalanos, J.J., and Calderwood, S.B., Heterologous antigen expression in Vibrio cholerae vector strains. Infect Immun, 1995. 63(7): p. 2689-96. PubMed |
| Waldor, M.K. and Mekalanos, J.J., Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype. J Infect Dis, 1994. 170(2): p. 278-83. PubMed | |
| Waldor, M.K. and Mekalanos, J.J., Vibrio cholerae O139 specific gene sequences. Lancet, 1994. 343(8909): p. 1366. PubMed | |
| Waldor, M.K. and Mekalanos, J.J., ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera. Infect Immun, 1994. 62(1): p. 72-8. PubMed | |
| Waldor, M.K., Colwell, R., and Mekalanos, J.J., The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants. Proc Natl Acad Sci U S A, 1994. 91(24): p. 11388-92. PubMed | |
| Slauch, J.M., Mahan, M.J., and Mekalanos, J.J., Measurement of transcriptional activity in pathogenic bacteria recovered directly from infected host tissue. Biotechniques, 1994. 16(4): p. 641-4. PubMed | |
| Slauch, J.M., Mahan, M.J., and Mekalanos, J.J., In vivo expression technology for selection of bacterial genes specifically induced in host tissues. Methods Enzymol, 1994. 235: p. 481-92. PubMed | |
| Michetti, P., Porta, N., Mahan, M.J., Slauch, J.M., Mekalanos, J.J., Blum, A.L., Kraehenbuhl, J.P., and Neutra, M.R., Monoclonal immunoglobulin A prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium. Gastroenterology, 1994. 107(4): p. 915-23. PubMed | |
| Mekalanos, J.J. and Sadoff, J.C., Cholera vaccines: fighting an ancient scourge. Science, 1994. 265(5177): p. 1387-9. PubMed | |
| Mekalanos, J.J., Live bacterial vaccines: environmental aspects. Curr Opin Biotechnol, 1994. 5(3): p. 312-9. PubMed | |
| Mekalanos, J.J., Live attenuated vaccine vectors. Int J Technol Assess Health Care, 1994. 10(1): p. 131-42. PubMed | |
| Gardel, C.L. and Mekalanos, J.J., Regulation of cholera toxin by temperature, pH, and osmolarity. Methods Enzymol, 1994. 235: p. 517-26. PubMed | |
| Dziejman, M. and Mekalanos, J.J., Analysis of membrane protein interaction: ToxR can dimerize the amino terminus of phage lambda repressor. Mol Microbiol, 1994. 13(3): p. 485-94. PubMed | |
| Camilli, A., Beattie, D.T., and Mekalanos, J.J., Use of genetic recombination as a reporter of gene expression. Proc Natl Acad Sci U S A, 1994. 91(7): p. 2634-8. PubMed | |
| Pearson, G.D., Woods, A., Chiang, S.L., and Mekalanos, J.J., CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor. Proc Natl Acad Sci U S A, 1993. 90(8): p. 3750-4. PubMed | |
| Mekalanos, J.J., Bacterial response to host signals: analysis and applications. Harvey Lect, 1993. 89: p. 1-13. PubMed | |
| Mahan, M.J., Slauch, J.M., and Mekalanos, J.J., Bacteriophage P22 transduction of integrated plasmids: single-step cloning of Salmonella typhimurium gene fusions. J Bacteriol, 1993. 175(21): p. 7086-91. PubMed | |
| Mahan, M.J., Slauch, J.M., and Mekalanos, J.J., Selection of bacterial virulence genes that are specifically induced in host tissues. Science, 1993. 259(5095): p. 686-8. PubMed | |
| Mahan, M.J., Slauch, J.M., Hanna, P.C., Camilli, A., Tobias, J.W., Waldor, M.K., and Mekalanos, J.J., Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors. Infect Agents Dis, 1993. 2(4): p. 263-8. PubMed | |
| Lin, Z., Kumagai, K., Baba, K., Mekalanos, J.J., and Nishibuchi, M., Vibrio parahaemolyticus has a homolog of the Vibrio cholerae toxRS operon that mediates environmentally induced regulation of the thermostable direct hemolysin gene. J Bacteriol, 1993. 175(12): p. 3844-55. PubMed | |
| Beattie, D.T., Mahan, M.J., and Mekalanos, J.J., Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis. J Bacteriol, 1993. 175(2): p. 519-27. PubMed | |
| Apter, F.M., Michetti, P., Winner, L.S., 3rd, Mack, J.A., Mekalanos, J.J., and Neutra, M.R., Analysis of the roles of antilipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo. Infect Immun, 1993. 61(12): p. 5279-85. PubMed | |
| Apter, F.M., Lencer, W.I., Finkelstein, R.A., Mekalanos, J.J., and Neutra, M.R., Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro. Infect Immun, 1993. 61(12): p. 5271-8. PubMed | |
| Parsot, C. and Mekalanos, J.J., Structural analysis of the acfA and acfD genes of Vibrio cholerae: effects of DNA topology and transcriptional activators on expression. J Bacteriol, 1992. 174(16): p. 5211-8. PubMed | |
| Ottemann, K.M., DiRita, V.J., and Mekalanos, J.J., ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter. J Bacteriol, 1992. 174(21): p. 6807-14. PubMed | |
| Miller, J.F., Johnson, S.A., Black, W.J., Beattie, D.T., Mekalanos, J.J., and Falkow, S., Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene. J Bacteriol, 1992. 174(3): p. 970-9. PubMed | |
| Michetti, P., Mahan, M.J., Slauch, J.M., Mekalanos, J.J., and Neutra, M.R., Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect Immun, 1992. 60(5): p. 1786-92. PubMed | |
| Mekalanos, J.J., Environmental signals controlling expression of virulence determinants in bacteria. J Bacteriol, 1992. 174(1): p. 1-7. PubMed | |
| Mekalanos, J.J., Bacterial mucosal vaccines. Adv Exp Med Biol, 1992. 327: p. 43-50. PubMed | |
| Killeen, K.P., Escuyer, V., Mekalanos, J.J., and Collier, R.J., Reversion of recombinant toxoids: mutations in diphtheria toxin that partially compensate for active-site deletions. Proc Natl Acad Sci U S A, 1992. 89(13): p. 6207-9. PubMed | |
| Beattie, D.T., Shahin, R., and Mekalanos, J.J., A vir-repressed gene of Bordetella pertussis is required for virulence. Infect Immun, 1992. 60(2): p. 571-7. PubMed | |
| Winner, L., 3rd, Mack, J., Weltzin, R., Mekalanos, J.J., Kraehenbuhl, J.P., and Neutra, M.R., New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect Immun, 1991. 59(3): p. 977-82. PubMed | |
| Parsot, C., Taxman, E., and Mekalanos, J.J., ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae. Proc Natl Acad Sci U S A, 1991. 88(5): p. 1641-5. PubMed | |
| Parsot, C. and Mekalanos, J.J., Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator. J Bacteriol, 1991. 173(9): p. 2842-51. PubMed | |
| Neutra, M., Weltzin, R., Winner, L., Mack, J., Michetti, P., Morrison, L., Fields, B.N., Mekalanos, J.J., and Kraehenbuhl, J.P., Identification and use of protective monoclonal IgA antibodies against viral and bacterial pathogens. Adv Exp Med Biol, 1991. 310: p. 179-82. PubMed | |
| Hall, R.H., Losonsky, G., Silveira, A.P., Taylor, R.K., Mekalanos, J.J., Witham, N.D., and Levine, M.M., Immunogenicity of Vibrio cholerae O1 toxin-coregulated pili in experimental and clinical cholera. Infect Immun, 1991. 59(7): p. 2508-12. PubMed | |
| Finn, T.M., Shahin, R., and Mekalanos, J.J., Characterization of vir-activated TnphoA gene fusions in Bordetella pertussis. Infect Immun, 1991. 59(9): p. 3273-9. PubMed | |
| DiRita, V.J., Parsot, C., Jander, G., and Mekalanos, J.J., Regulatory cascade controls virulence in Vibrio cholerae. Proc Natl Acad Sci U S A, 1991. 88(12): p. 5403-7. PubMed | |
| DiRita, V.J. and Mekalanos, J.J., Periplasmic interaction between two membrane regulatory proteins, ToxR and ToxS, results in signal transduction and transcriptional activation. Cell, 1991. 64(1): p. 29-37. PubMed | |
| Sun, D.X., Mekalanos, J.J., and Taylor, R.K., Antibodies directed against the toxin-coregulated pilus isolated from Vibrio cholerae provide protection in the infant mouse experimental cholera model. J Infect Dis, 1990. 161(6): p. 1231-6. PubMed | |
| Soltis, M.T., Mekalanos, J.J., and Betley, M.J., Identification of a bacteriophage containing a silent staphylococcal variant enterotoxin gene (sezA+). Infect Immun, 1990. 58(6): p. 1614-9. PubMed | |
| Pearson, G.D., DiRita, V.J., Goldberg, M.B., Boyko, S.A., Calderwood, S.B., and Mekalanos, J.J., New attenuated derivatives of Vibrio cholerae. Res Microbiol, 1990. 141(7-8): p. 893-9. PubMed | |
| Parsot, C. and Mekalanos, J.J., Expression of ToxR, the transcriptional activator of the virulence factors in Vibrio cholerae, is modulated by the heat shock response. Proc Natl Acad Sci U S A, 1990. 87(24): p. 9898-902. PubMed | |
| Miller, S.I., Pulkkinen, W.S., Selsted, M.E., and Mekalanos, J.J., Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium. Infect Immun, 1990. 58(11): p. 3706-10. PubMed | |
| Miller, S.I., Mekalanos, J.J., and Pulkkinen, W.S., Salmonella vaccines with mutations in the phoP virulence regulon. Res Microbiol, 1990. 141(7-8): p. 817-21. PubMed | |
| Miller, S.I. and Mekalanos, J.J., Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages. J Bacteriol, 1990. 172(5): p. 2485-90. PubMed | |
| Manoil, C., Mekalanos, J.J., and Beckwith, J., Alkaline phosphatase fusions: sensors of subcellular location. J Bacteriol, 1990. 172(2): p. 515-8. PubMed | |
| Lee, C.K., Roberts, A.L., Finn, T.M., Knapp, S., and Mekalanos, J.J., A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations. Infect Immun, 1990. 58(8): p. 2516-22. PubMed | |
| Beattie, D.T., Knapp, S., and Mekalanos, J.J., Evidence that modulation requires sequences downstream of the promoters of two vir-repressed genes of Bordetella pertussis. J Bacteriol, 1990. 172(12): p. 6997-7004. PubMed |
| Taylor, R.K., Manoil, C., and Mekalanos, J.J., Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae. J Bacteriol, 1989. 171(4): p. 1870-8. PubMed | |
| Miller, V.L., DiRita, V.J., and Mekalanos, J.J., Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter. J Bacteriol, 1989. 171(3): p. 1288-93. PubMed | |
| Miller, S.I. and Mekalanos, J.J., Strategies for the development of vaccines for typhoid fever, shigellosis, and cholera. Ann N Y Acad Sci, 1989. 569: p. 145-54. PubMed | |
| Miller, S.I., Kukral, A.M., and Mekalanos, J.J., A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence. Proc Natl Acad Sci U S A, 1989. 86(13): p. 5054-8. PubMed | |
| Miller, J.F., Mekalanos, J.J., and Falkow, S., Coordinate regulation and sensory transduction in the control of bacterial virulence. Science, 1989. 243(4893): p. 916-22. PubMed | |
| DiRita, V.J. and Mekalanos, J.J., Genetic regulation of bacterial virulence. Annu Rev Genet, 1989. 23: p. 455-82. PubMed | |
| Taylor, R., Shaw, C., Peterson, K., Spears, P., and Mekalanos, J., Safe, live Vibrio cholerae vaccines? Vaccine, 1988. 6(2): p. 151-4. PubMed | |
| Pierce, N.F., Cray, W.C., Jr., Kaper, J.B., and Mekalanos, J.J., Determinants of immunogenicity and mechanisms of protection by virulent and mutant Vibrio cholerae O1 in rabbits. Infect Immun, 1988. 56(1): p. 142-8. PubMed | |
| Peterson, K.M. and Mekalanos, J.J., Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization. Infect Immun, 1988. 56(11): p. 2822-9. PubMed | |
| Miller, V.L. and Mekalanos, J.J., A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol, 1988. 170(6): p. 2575-83. PubMed | |
| Mekalanos, J.J., Peterson, K.M., Finn, T., and Knapp, S., The pathogenesis and immunology of Vibrio cholerae and Bordetella pertussis. Antonie Van Leeuwenhoek, 1988. 54(5): p. 379-87. PubMed | |
| Mekalanos, J.J., Production and purification of cholera toxin. Methods Enzymol, 1988. 165: p. 169-75. PubMed | |
| Knapp, S. and Mekalanos, J.J., Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis. J Bacteriol, 1988. 170(11): p. 5059-66. PubMed | |
| Hovde, C.J., Calderwood, S.B., Mekalanos, J.J., and Collier, R.J., Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I. Proc Natl Acad Sci U S A, 1988. 85(8): p. 2568-72. PubMed | |
| Herrington, D.A., Hall, R.H., Losonsky, G., Mekalanos, J.J., Taylor, R.K., and Levine, M.M., Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans. J Exp Med, 1988. 168(4): p. 1487-92. PubMed | |
| Hall, R.H., Vial, P.A., Kaper, J.B., Mekalanos, J.J., and Levine, M.M., Morphological studies on fimbriae expressed by Vibrio cholerae 01. Microb Pathog, 1988. 4(4): p. 257-65. PubMed | |
| Calderwood, S.B. and Mekalanos, J.J., Confirmation of the Fur operator site by insertion of a synthetic oligonucleotide into an operon fusion plasmid. J Bacteriol, 1988. 170(2): p. 1015-7. PubMed | |
| Betley, M.J. and Mekalanos, J.J., Nucleotide sequence of the type A staphylococcal enterotoxin gene. J Bacteriol, 1988. 170(1): p. 34-41. PubMed | |
| Taylor, R.K., Miller, V.L., Furlong, D.B., and Mekalanos, J.J., Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. Proc Natl Acad Sci U S A, 1987. 84(9): p. 2833-7. PubMed | |
| Pierce, N.F., Kaper, J.B., Mekalanos, J.J., Cray, W.C., Jr., and Richardson, K., Determinants of the immunogenicity of live virulent and mutant Vibrio cholerae O1 in rabbit intestine. Infect Immun, 1987. 55(2): p. 477-81. PubMed | |
| Miller, V.L., Taylor, R.K., and Mekalanos, J.J., Cholera toxin transcriptional activator toxR is a transmembrane DNA binding protein. Cell, 1987. 48(2): p. 271-9. PubMed | |
| Chopra, A.K., Houston, C.W., Peterson, J.W., Prasad, R., and Mekalanos, J.J., Cloning and expression of the Salmonella enterotoxin gene. J Bacteriol, 1987. 169(11): p. 5095-100. PubMed | |
| Calderwood, S.B. and Mekalanos, J.J., Iron regulation of Shiga-like toxin expression in Escherichia coli is mediated by the fur locus. J Bacteriol, 1987. 169(10): p. 4759-64. PubMed | |
| Calderwood, S.B., Auclair, F., Donohue-Rolfe, A., Keusch, G.T., and Mekalanos, J.J., Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli. Proc Natl Acad Sci U S A, 1987. 84(13): p. 4364-8. PubMed | |
| Taylor, R.K., Miller, V.L., Furlong, D.B., and Mekalanos, J.J., Identification of a pilus colonization factor that is coordinately regulated with cholera toxin. Ann Sclavo Collana Monogr, 1986. 3(1-2): p. 51-61. PubMed | |
| Goldberg, I. and Mekalanos, J.J., Effect of a recA mutation on cholera toxin gene amplification and deletion events. J Bacteriol, 1986. 165(3): p. 723-31. PubMed | |
| Goldberg, I. and Mekalanos, J.J., Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant. J Bacteriol, 1986. 165(3): p. 715-22. PubMed | |
| Betley, M.J., Miller, V.L., and Mekalanos, J.J., Genetics of bacterial enterotoxins. Annu Rev Microbiol, 1986. 40: p. 577-605. PubMed | |
| Watkins, P.A., Yost, D.A., Chang, A.W., Mekalanos, J.J., and Moss, J., Detection of NAD:arginine ADPribosyltransferases in animal tissues using 125I-labeled 1-(p-hydroxyphenyl) 2-guanidinoethane as ADPribose acceptor. Biochim Biophys Acta, 1985. 840(3): p. 401-8. PubMed | |
| Pierce, N.F., Kaper, J.B., Mekalanos, J.J., and Cray, W.C., Jr., Role of cholera toxin in enteric colonization by Vibrio cholerae O1 in rabbits. Infect Immun, 1985. 50(3): p. 813-6. PubMed | |
| Miller, V.L. and Mekalanos, J.J., Genetic analysis of the cholera toxin-positive regulatory gene toxR. J Bacteriol, 1985. 163(2): p. 580-5. PubMed | |
| Mekalanos, J.J., Cholera toxin: genetic analysis, regulation, and role in pathogenesis. Curr Top Microbiol Immunol, 1985. 118: p. 97-118. PubMed | |
| Betley, M.J. and Mekalanos, J.J., Staphylococcal enterotoxin A is encoded by phage. Science, 1985. 229(4709): p. 185-7. PubMed | |
| Sporecke, I., Castro, D., and Mekalanos, J.J., Genetic mapping of Vibrio cholerae enterotoxin structural genes. J Bacteriol, 1984. 157(1): p. 253-61. PubMed |
| Miller, V.L. and Mekalanos, J.J., Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR. Proc Natl Acad Sci U S A, 1984. 81(11): p. 3471-5. PubMed | |
| Mekalanos, J.J., Swartz, D.J., Pearson, G.D., Harford, N., Groyne, F., and de Wilde, M., Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature, 1983. 306(5943): p. 551-7. PubMed | |
| Mekalanos, J.J., Duplication and amplification of toxin genes in Vibrio cholerae. Cell, 1983. 35(1): p. 253-63. PubMed | |
| Pearson, G.D. and Mekalanos, J.J., Molecular cloning of Vibrio cholerae enterotoxin genes in Escherichia coli K-12. Proc Natl Acad Sci U S A, 1982. 79(9): p. 2976-80. PubMed | |
| Mekalanos, J.J., Moseley, S.L., Murphy, J.R., and Falkow, S., Isolation of enterotoxin structural gene deletion mutations in Vibrio cholerae induced by two mutagenic vibriophages. Proc Natl Acad Sci U S A, 1982. 79(1): p. 151-5. PubMed | |
| Mekalanos, J.J. and Murphy, J.R., Regulation of cholera toxin production in Vibrio cholerae: genetic analysis of phenotypic instability in hypertoxinogenic mutants. J Bacteriol, 1980. 141(2): p. 570-6. PubMed | |
| Wisnieski, B.J., Shiflett, M.A., Mekalanos, J., and Bramhall, J.S., Analysis of transmembrane dynamics of cholera toxin using photoreactive probes. J Supramol Struct, 1979. 10(2): p. 191-7. PubMed | |
| Mekalanos, J.J., Sublett, R.D., and Romig, W.R., Genetic mapping of toxin regulatory mutations in Vibrio cholerae. J Bacteriol, 1979. 139(3): p. 859-65. PubMed | |
| Mekalanos, J.J., Collier, R.J., and Romig, W.R., Enzymic activity of cholera toxin. I. New method of assay and the mechanism of ADP-ribosyl transfer. J Biol Chem, 1979. 254(13): p. 5849-54. PubMed | |
| Mekalanos, J.J., Collier, R.J., and Romig, W.R., Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition. J Biol Chem, 1979. 254(13): p. 5855-61. PubMed | |
| Mekalanos, J.J., Collier, R.J., and Romig, W.R., Purification of cholera toxin and its subunits: new methods of preparation and the use of hypertoxinogenic mutants. Infect Immun, 1978. 20(2): p. 552-8. PubMed | |
| Mekalanos, J.J., Collier, R.J., and Romig, W.R., Affinity filters, a new approach to the isolation of tox mutants of Vibrio cholerae. Proc Natl Acad Sci U S A, 1978. 75(2): p. 941-5. PubMed | |
| Mekalanos, J.J., Collier, R.J., and Romig, W.R., Simple method for purifying choleragenoid, the natural toxoid of Vibrio cholerae. Infect Immun, 1977. 16(3): p. 789-95. PubMed |